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入学希望の方一般・社会人の方研究者の方同窓生の方在学生の方教職員の方 日本語 (Japanese) Graduate School of Life Sciences, Tohoku University Access sitemap Link Tohoku University HOMEAbout UsAbout UsMessage from the DeanOrganizationMovieResearchLaboratories Department of Integrative Life Sciences Department of Ecological Developmental Adaptability Life Sciences Department of Molecular and Chemical Life SciencesResearchAwardEducationDegree ProgramsCourseSyllabusScheduleStudent LifeAdmissionAdmission InformationApplicationExamination Schedule and Application GuidelinesInformation Session(2024)Admission and Tuition FeesAdmission PolicyVoices from Graduates and Current StudentsAdmissions Q&AInquiries about Entrance ExaminationsFinancial SupportFor StudentsGraduate School&＃039;s Message Board for Students Information about Completion and Advancement to the Doctoral Course ProceduresCertificatesAbout Issuance of Various CertificatesNotice Regarding the Suspension of Operation of the Automatic Certificate Issuing MachinesLeave of absence/withdrawal from universityCampus Life, Various consultation servicesContactAccessLinkSitemapInformationAdmissionResearchAwardSeminarJobNewsAnnouncementOther MENU HOMEAbout UsAbout UsMessage from the DeanOrganizationMovieResearchLaboratoriesResearchAwardEducationDegree ProgramsCourseSyllabusScheduleStudent LifeAdmissionAdmission InformationApplicationExamination Schedule and Application GuidelinesInformation Session(2024)Admission and Tuition FeesAdmission PolicyVoices from Graduates and Current StudentsAdmissions Q&AInquiries about Entrance ExaminationsFinancial SupportFor StudentsGraduate School&＃039;s Message Board for Students Information about Completion and Advancement to the Doctoral Course ProceduresCertificatesLeave of absence/withdrawal from universityCampus Life, Various consultation servicesContactAccessLinkSitemapInformationAdmissionResearchAwardSeminarJobNewsAnnouncementOther 日本語 (Japanese) CLOSE Graduate School of Life Sciences, Tohoku University. Field Molecular and Chemical Life Science :Multilevel Biomolecular Structure and Dynamics Research HOME Research Researcher JAPANESE Associate Professor OKUMURA Masaki (C) Campus Katahira campus Laboratory Molecular Analysis of Biological Functions Tel +81-22-795-5764 E-mail okmasaki＠tohoku.ac.jp Website https://web.tohoku.ac.jp/okumura/# Researchmap: https://researchmap.jp/7000017803?lang=en   Career 2006　    B.S. Kwansei Gakuin University School of Science 2010    Research Fellowship for Young Scientists, JSPS DC2 (Kwansei Gakuin University) 2011     Ph.D. Kwansei Gakuin University School of Science and Technology 2011    Research Fellowship for Young Scientists, JSPS PD (Kwansei Gakuin University) 2012    Post-doctor (Kyushu University) 2013     Research Fellowship for Young Scientists, JSPS PD (Tohoku University) 2016    Assistant Professor (Institute of Multidisciplinary Research for Advanced Materials, Tohoku University) 2017     Assistant Professor (Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Japan, Tohoku University) 2022     Associate Professor (Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Japan, Tohoku University)   Selected Publications Okumura, M.*, Kanemura, S., Matsusaki, M., Kinoshita, M., Saio, T., Ito, D., Hirayama, C., Kumeta, H., Watabe, M., Amagai, Y., Lee, Y.H., Akiyama, S., and Inaba, K.* “A unique leucine-valine adhesive motif supports structure and function of protein disulfide isomerase P5 via dimerization” Structure 29 1-14 (2021) Okumura, M., Noi, K., and Inaba, K.* “Visualization of structural dynamics of protein disulfide isomerase enzymes in catalysis of oxidative folding and reductive unfolding” Current Opinion in Structural Biology 66 49-57 (2021) Matsusaki, M., Okada, R., Tanikawa, Y., Kanemura, S., Ito, D., Lin, Y., Watabe, M., Yamaguchi, H., Saio, T., Lee, YH., Inaba, K., and Okumura, M.* “Functional Interplay Between P5 And PDI/ERp72 To Drive Protein Folding” Biology 10(11) 1112 (2021) Matsusaki, M., Kanemura, S., Kinoshita, M., Lee, Y.H., Inaba, K.,* and Okumura, M.* “The Protein Disulfide Isomerase family: from Proteostasis to Pathogenesis” Biochim Biophys Acta-general subjects 1864 129338 (2020) Okumura, M.*, Noi, K., Kanemura, S., Kinoshita, M., Saio, T., Inoue, Y., Hikima, T., Akiyama, S., Ogura, T.* and Inaba, K.* “Dynamic assembly of protein disulfide isomerase in catalysis of oxidative folding” Nature Chemical Biology 15, 499-509 (2019) Okada, S., Matsusaki, M., Arai, K., Hidaka, Y., Inaba, K., Okumura, M.*, and Muraoka, T.* “Coupling effects of thiol and urea-type groups for promotion of oxidative protein folding” Chem Commun (Camb) 55 759-762 (2019)   Activities in Academic Societies Protein Science Society of Japan, the Molecular Biology Society of Japan Teaching Biology A, Biology B Recent Activities Protein folding coupled with disulfide bond formation, that is oxidative protein folding, proceeds mainly in the endoplasmic reticulum (ER). Greater than 20 Protein Disulfide Isomerase family members (PDIs) are conserved in the mammalian ER to catalyze this reaction. However, it remains an important open question how PDIs recognize various substrates and guide their proper folding through disulfide bond formation and isomerization. The goal of this study is to understand how protein homeostasis is maintained in the mammalian ER. To this end, I employ multiple approaches including single-molecule observation by high-speed AFM, NMR/SAXS analyses in solution, X-ray crystal structure analysis, and several biochemical assays. Diabetes and neurodegenerative diseases are caused by impairment of the protein quality control systems in cells, and hence this study will provide molecular insights into the mechanism underlying these diseases. ResearchLaboratories Department of Integrative Life Sciences Department of Ecological Developmental Adaptability Life Sciences Department of Molecular and Chemical Life SciencesResearchAward GO TOP Graduate School of Life SciencesTohoku University 2-1-1 Katahira, Aoba-Ku, Sendai 980-8577 Academic Affairs Section Tel : +81-22-217-5706 / Fax: +81-22-217-5704   General Affairs Section Tel : +81-22-217-5702 / Fax: +81-22-217-5704   Contact ・Privacy Policy HOMEAbout UsAbout UsMessage from the DeanOrganizationMovieResearchLaboratories Department of Integrative Life Sciences Department of Ecological Developmental Adaptability Life Sciences Department of Molecular and Chemical Life SciencesResearchAwardEducationDegree ProgramsCourseSyllabusScheduleStudent LifeAdmissionAdmission InformationApplicationExamination Schedule and Application GuidelinesInformation Session(2024)Admission and Tuition FeesAdmission PolicyVoices from Graduates and Current StudentsAdmissions Q&AInquiries about Entrance ExaminationsFinancial SupportFor StudentsGraduate School&＃039;s Message Board for Students Information about Completion and Advancement to the Doctoral Course ProceduresCertificatesAbout Issuance of Various CertificatesNotice Regarding the Suspension of Operation of the Automatic Certificate Issuing MachinesLeave of absence/withdrawal from universityCampus Life, Various consultation servicesContactAccessLinkSitemapInformationAdmissionResearchAwardSeminarJobNewsAnnouncementOther © 2004-2023 Graduate School of Life Sciences, Tohoku University no cache