ステークカジノダイス

入学希望の方一般・社会人の方研究者の方同窓生の方在学生の方教職員の方 日本語 (Japanese) Graduate School of Life Sciences, Tohoku University Access sitemap Link Tohoku University HOMEAbout UsAbout UsMessage from the DeanOrganizationMovieResearchLaboratories Department of Integrative Life Sciences Department of Ecological Developmental Adaptability Life Sciences Department of Molecular and Chemical Life SciencesResearchAwardEducationDegree ProgramsCourseSyllabusScheduleStudent LifeAdmissionAdmission InformationApplicationExamination Schedule and Application GuidelinesInformation Session(2024)Admission and Tuition FeesAdmission PolicyVoices from Graduates and Current StudentsAdmissions Q&AInquiries about Entrance ExaminationsFinancial SupportFor StudentsGraduate School&＃039;s Message Board for Students Information about Completion and Advancement to the Doctoral Course ProceduresCertificatesAbout Issuance of Various CertificatesNotice Regarding the Suspension of Operation of the Automatic Certificate Issuing MachinesLeave of absence/withdrawal from universityCampus Life, Various consultation servicesContactAccessLinkSitemapInformationAdmissionResearchAwardSeminarJobNewsAnnouncementOther MENU HOMEAbout UsAbout UsMessage from the DeanOrganizationMovieResearchLaboratoriesResearchAwardEducationDegree ProgramsCourseSyllabusScheduleStudent LifeAdmissionAdmission InformationApplicationExamination Schedule and Application GuidelinesInformation Session(2024)Admission and Tuition FeesAdmission PolicyVoices from Graduates and Current StudentsAdmissions Q&AInquiries about Entrance ExaminationsFinancial SupportFor StudentsGraduate School&＃039;s Message Board for Students Information about Completion and Advancement to the Doctoral Course ProceduresCertificatesLeave of absence/withdrawal from universityCampus Life, Various consultation servicesContactAccessLinkSitemapInformationAdmissionResearchAwardSeminarJobNewsAnnouncementOther 日本語 (Japanese) CLOSE Graduate School of Life Sciences, Tohoku University. Field Integrative Life Sciences :Developmental Regulation Network Research HOME Research Researcher JAPANESE Professor MATSUI Yasuhisa Campus Seiryo campus Laboratory Germ Cell Development Tel +81-22-717-8571 E-mail yasuhisa.matsui.d3＠tohoku.ac.jp Website http://www2.idac.tohoku.ac.jp/dep/crcbr/ Google Scholar https://scholar.google.co.jp/citations?user=S945s7IAAAAJ&hl=ja While studying abroad in the U.S., I happened to become involved in research concerning the development of reproductive cells. Since that time, I have been obsessed with and spent my life absorbed in the research of the wondrous properties of reproductive cells, which possess the ability to produce an entire individual organism. Career 1983 Graduated, Faculty of Pharmaceutical Science, University of Tokyo 1988 Completed Graduate School of Pharmaceutical Sciences, University of Tokyo 1988-1992 Post-doctoral Fellow, School of Medicine, Vanderbilt University (U.S.A.) 1992-1998 Assistant and Assistant Professor, Research Institute of　tuberculosis and Cancer,, Tohoku University 1998-2004 Laboratory Head, Osaka Medical Center for Maternal and Child Health 2004-present Current position Selected Publications . Ota, H, Ito-Matsuoka, Y., Matsui, Y. Identification of the X-linked germ cell specific miRNAs (XmiRs) and their functions. PLoS ONE 14, e0211739 (2019). An, Y., Sekinaka, T., Tando, Y., Okamura, D., Tanaka, K., Ito-Matsuoka, Y., Takehara, A., Yaegashi, N., Matsui, Y.  Derivation of pluripotent stem cells from nascent undifferentiated teratoma. Developmental Biology 446, 43-55 (2019). Mochizuki, K., Tando, Y., Sekinaka, T., Otsuka, K., Hayashi, Y., Kobayashi, H., Kamio, A., Ito-Matsuoka, Y., Takehara, A., Kono, T., Osumi, N., Matsui, Y. SETDB1 is essential for mouse primordial germ cell fate determination by ensuring BMP signaling. Development 145, dev164160 (2018). Tatsumi, D., Hayashi, Y., Endo, M., Kobayashi, H., Yoshioka, T., Kiso, K., Kanno, S., Nakai, Y., Maeda, I., Mochizuki, K., Tachibana, M., Koseki, H., Okuda, A., Yasui, A., Kono, K., Matsui, Y. DNMTs and SETDB1 function as co-repressors in MAX-mediated repression of germ cell–related genes in mouse embryonic stem cells. PLoS ONE 13, e0205969 (2018). Otsuka, K., Takehara, A., Chiba, N., Matsui, Y. Identification of KLF9 and BCL3 as transcription factors that enhance reprogramming of primordial germ cells. PLoS ONE 13, e0205004 (2018). Mochizuki, K., Hayashi, H., Sekinaka, T., Otsuka, K., Ito-Matsuoka, Y., Kobayashi, H., Oki, S., Takehara, A., Kono, T., Osumi, N., Matsui, Y.  Repression of somatic genes by selective recruitment of HDAC3 by BLIMP1 is essential for mouse primordial germ cell fate determination. Cell Reports 24, 2682–2693 (2018). Gu, W., Mochizuki, K., Otsuka, K., Hamada, R., Takehara, A., Matsui, Y. Dnd1-mediated epigenetic control of teratoma formation in mouse. Biology Open 7, bio030106 (2018). Hayashi, Y., Otsuka, K., Ebina, M., Igarashi, K., Takehara, A., Matsumoto, M., Kanai, A., Igarashi, K., Soga, T., Matsui, Y. Distinct requirements for energy metabolism in mouse primordial germ cells and their reprogramming to embryonic germ cells.  Proceedings of National Academy of Science, USA. 114, 8286-8294 (2017). Aoki, N., Mochizuki, K., Matsui, Y. DNA Methylation of the Fthl17 5’-Upstream Region Regulates Differential Fthl17 Expression in Lung Cancer Cells and Germline Stem Cells.  PLoS ONE 12, e0172219 (2017).   Activities in Academic Societies Japanese Society of Developmental Biologists The Molecular Biology Society of Japan Teaching Advanced Lecture on Mechanisms of Cellular Differentiation Recent Activities Reproductive cells specialize from pluripotential stem cells into primordial germ cells during the initial stage of embryonic development and then further mature into sperm and eggs. Epigenetic control plays an important role in this process via the methylation of DNA and histones. What we have learned from our recent research is that the methylation of a particular histone serves to stop the specialization of pluripotential stem cells to germ cells. In addition, we have also found out that the demethylation of DNA and the methylation of histone combine, causing the expression of specific genes in response to the stage of germ cell differfentiation. Message to Students Although research is a fascinating job, good results rarely appear in line with what you expected. If things do not go well, you consider this and that, consult with the people around you, and occasionally spend days trying to solve the problem. When you finally solve the problem yourself, however, it is an extremely happy feeling, and if it leads to some new result, it is like reaching the limit of ecstasy. I would like to have many people participate in our research and experience the roller coaster-like excitement. 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