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-->   Nobuaki Matsumori Last modified date：2024.04.20 Professor / Inorganic Chemistry and Analytical Chemistry Department of Chemistry Faculty of Sciences 1 Research Interests 2 Academic Activities 2.1 Books 2.2 Papers 2.3 Reports 2.4 Presentations 3 Membership in Academic Society 4 Awards 5 Educational Activities 6 Other Educational Activities Graduate School Department of Chemistry Graduate School of Sciences Undergraduate School Department of Chemistry School of Sciences E-Mail　*Since the e-mail address is not displayed in Internet Explorer, please use another web browser:Google Chrome, safari. Homepage https://kyushu-u.elsevierpure.com/en/persons/nobuaki-matsumori　Reseacher Profiling Tool　Kyushu University Pure http://www.scc.kyushu-u.ac.jp/BioanalChem/index.htmlDepartment of Chemistry, Kyushu University, Latoratory of Bioanalytical Chemistry . Phone 092-802-4153 Fax 092-802-4153 Academic Degree Doctor of Science Country of degree conferring institution (Overseas) No Field of Specialization Bioanalytical chemistry, Chemical biology, Natural products chemistry ORCID(Open Researcher and Contributor ID) 0000-0003-0495-2044 Total Priod of education and research career in the foreign country 01years00months Outline Activities To totally understand biomembranes including membrane proteins, we performed integrated analyses of membranes by using various methods of not only analytical chemistry but also organic chemistry, chemical biology, and structure biology. In more detail, we are studying lipid rafts and lipid diversity for the basic understanding of biomembranes, and mechanism of action of membrane-acting drugs such as anesthetics. Research Research Interests Bioanalytical chemistrykeyword : biomembranes, bioanalysis2014.07～2024.12. Academic Activities Books  Show All Books >> Reports  Show All Reports >> Papers  Show All Papers >> 1. Masanao Kinoshita, Kenichi G.N. Suzuki, Nobuaki Matsumori, Misa Takada, Hikaru Ano, Kenichi Morigaki, Mitsuhiro Abe, Asami Makino, Toshihide Kobayashi, Koichiro M. Hirosawa, Takahiro K. Fujiwara, Akihiro Kusumi, Michio Murata, Raft-based sphingomyelin interactions revealed by new fluorescent sphingomyelin analogs, Journal of Cell Biology, 10.1083/jcb.201607086, 216, 4, 1183-1204, 2017.04, Sphingomyelin (SM) has been proposed to form cholesterol-dependent raft domains and sphingolipid domains in the plasma membrane (PM). How SM contributes to the formation and function of these domains remains unknown, primarily because of the scarcity of suitable fluorescent SM analogs. We developed new fluorescent SM analogs by conjugating a hydrophilic fluorophore to the SM choline headgroup without eliminating its positive charge, via a hydrophilic nonaethylene glycol linker. The new analogs behaved similarly to the native SM in terms of their partitioning behaviors in artificial liquid order-disorder phase-separated membranes and detergent-resistant PM preparations. Single fluorescent molecule tracking in the live-cell PM revealed that they indirectly interact with each other in cholesterol- and sphingosine backbone-dependent manners, and that, for ~10-50 ms, they undergo transient colocalization-codiffusion with a glycosylphosphatidylinositol (GPI)-anchored protein, CD59 (in monomers, transient-dimer rafts, and clusters), in CD59-oligomer size-, cholesterol-, and GPI anchoring-dependent manners. These results suggest that SM continually and rapidly exchanges between CD59-associated raft domains and the bulk PM.. 2. 松森 信明, Detailed Comparison of Deuterium Quadrupole Profiles between Sphingomyelin and Phosphatidylcholine Bilayers, BIOPHYSICAL JOURNAL, 10.1016/j.bpj.2013.12.034, 106, 3, 631-638, 2014.02. Presentations  Show All Presentations >> 1. 松森 信明, Small molecule interactions with membrane sterol, Pacifichem2015, 2015.12. 2. 松森 信明, NMR studies of lipid rafts, Pacifichem2015, 2015.12. Membership in Academic Society The Biophysical Society of Japan Biophysical Society American Chemical Society Chemical Society of Japan Awards Stereochemical determination of acyclic natural products on the basis of long-range C-H spin coupling constants Educational Educational Activities Chemistry in Daily LifeAnalytical Chemistry IAdvanced Analytical Chemistry IIAnalytical Chemistry IIIAnalytical Chemistry Experiment Other Educational Activities 2017.12, Opponent of the dissertation at Abo Akademi University, Finland.. Unauthorized reprint of the contents of this database is prohibited. Copyright © 2006, Kyushu University. All rights reserved.