ステークカジノ評判 徹底解説｜stakeカジノ レビュー2024 年

International Affairs Students Current Students Alumni Faculty/Staff Careers--> TOHOKU UNIVERSITYCREATING GLOBAL EXCELLENCE Search 日本語 Contact Tohoku University --> About Facts & Figures Facilities Organization Chart History President's Message Top Global University Project Designated National University Global Network Promotional Videos Academics Undergraduate Graduate Courses in English Exchange Programs Summer Programs Double Degree Programs Academic Calendar Syllabus Admissions Undergraduate Admissions Graduate Admissions Fees and Expenses Financial Aid Research Feature Highlights Research Releases University Research News Research Institutes Visitor Research Center Research Profiles Academic Research Staff Campus Life International Support Office IT Services Facilities Dining & Shops Campus Bus Clubs & Circles News University News Research--> Arts & Culture Health & Sports Campus & Community Press Release--> International Visit Alumni Careers Events Exhibits Music Special Event Lecture Alumni--> Map & Directions Campus Maps & Bus--> Facilities Map--> TOHOKUUNIVERSITY About Academics Admissions Research Campus Life News Events International Affairs Students Current Students Alumni Faculty/Staff Promotional Videos Subscribe to our Newsletter Map & Directions Contact Jobs & Vacancies Emergency Information Site Map 日本語 Close Home Research Feature Highlights Understanding Muscles Feature Highlights Understanding Muscles The advancement of science and genetics over the last few decades has greatly enhanced our understanding of skeletal muscle biology. At Tohoku University's Department of Health and Sports Science, Professor Ryoichi Nagatomi has been studying the body's adaptation to physical training, and the practical application of exercise towards attaining good health. His primary interest is in understanding the processes of skeletal muscle regeneration and fibrosis, the impact of physical stress on the immune system and the preventive aspect of physical activity and exercise. Professor Ryoichi Nagatomi has been studying the body's adaptation to physical training, especially skeletal muscle regeneration after an injury. The Mechanics: Muscle fibers get damaged when muscles are used at their full capacity. But they heal quickly because the body has a reserve supply of muscle stem cells called satellite cells. The self-renewing properties of satellite cells not only maintains the muscle stem cell population in the body, but also provides myogenic cells, which proliferate, differentiate, fuse, and lead to the formation of new myofibers whenever necessary to repair the damage. "In a couple of weeks, new muscles are made, so you're ok even if you damage some of your muscle fibers during intense training. In fact, this replacement of damaged fibers is the process by which we gain muscle strength," says Nagatomi. But hard and tough training doesn't always bring about the desired results. A muscle injury called laceration can sometimes develop, causing sudden pain and weakness during training. When that occurs, the repair process is slowed down because laceration creates too much space within the muscle tissue. Satellite cells do not develop into myogenic cells when there is too much space. Instead, they develop into myofibroblasts. Myofibroblasts produce a lot of matrix proteins such as collagen to fill the space and make a fibrotic tissue within the muscle. "Collagen fibers serve as a new directional guide to regenerating muscle fibers, telling them which way to grow, but it takes a long time to be repaired once you have the fibrotic tissue." Even without laceration, too much of intense training may also induce myofibroblasts. So Nagatomi recommends intense training, but less frequently- perhaps every other day instead of daily - to avoid developing fibrotic changes. The Switch: To address the complications of fibrotic changes after excess muscle damage, Nagatomi has been studying the effectiveness of using a molecular switch, by inactivating one, or changing the balance between two, proteins. "We injured the muscle of a mouse under anesthesia, then tried to switch on and off the molecular switch to drive the satellite cells towards successful repair of the muscle during the course of damage. And we found that it worked. The mouse had serious damage in its muscle but it recovered very quickly without fibrotic changes." But upon further analyses, Nagatomi and his team found a problem. "It was ok for muscle regeneration but by switching the protein, we found that we had used up all the satellite cells. Usually if you look into the muscle tissue, you find satellite cells everywhere even after the damage-repair process. But in the recovered muscle after switching the protein, we found no satellite cells. That means that if you damage that muscle again, it will not recover. And that's not good." The focus now for Nagatomi, is to further explore the feasibility of switching, by findings ways to keep usable satellite cells from disappearing after a switch. Training Smart: Although muscle damage and recovery is a natural occurrence, Nagatomi says it is important to acknowledge that everyone has different potential and physical strengths. In other words, there are smart ways to train. "If the coach asks for 30 sit-ups, those who have a limit of 30 would get the best benefits. For those who can do 50, the 30 won't maximize the use of their muscles. For those who can only do up to 20, then 20 is sufficient stimuli for their muscles to develop. "Here in Japan, people don't realize the importance of maximizing individual potential. They love doing drills but they don't give enough thought to why they are doing the drills. If you have more strength, will you definitely be better? Not always! It's more important that you have the skills to make good use of the muscles you have." Through the understanding of muscle development and growth, potential can be maximized and injury avoided during training. Why Muscles are Important: While muscle training is often associated with sports, the importance of muscles in daily life cannot be overstated. In fact, even though it may not always be obvious, a wide range of muscles are used every day in simple, basic activities. "Without muscles you can't move, you can't do exercise, you can't live independently," says Nagatomi. "Older people have weaker bones, so it's even more important that they have good muscles so they don't fall. Muscles are as important as your brain. It's one of the systems that maintains not just your lifestyle but also your life." Nagatomi wants his research to be applicable to practical, daily life, stressing that "science is for everyone, not just the researcher." To that end, a population study involving more than a thousand people is on-going, to find out if external factors - such as diet and environment - can also impact muscle growth and recovery. Links: Medicine & Science in Sports & Exercise Professor Ryoichi Nagatomi Vice dean of Tohoku University's Graduate School of Biomedical Engineering Professor of Health and Sports Science at the School of Medicine. Awards Medal of Honor with Purple Ribbon -- 2014 Japan Institute of Metals, Masumoto Hakaru Award -- 2013 Honorary Doctorate from the Institut National Polytechnique de Lorraine, France -- 2009 Honda Frontier Award -- 2008 Jean-Marie Dubois Award -- 2005Japan IBM Science Award -- 1994--> Feature Highlights 2018-05-11 In Conversation with Susumu Satomi 2018-04-04 Motoko Kotani: By the Numbers 2018-02-02 Yoshimichi Sato: Making Rational Choices 2017-09-07 Anawat Suppasri - Carried by the Waves 2017-05-30 Kyoko Sengoku-Haga: A Portrait of the Artist as an Historian 2017-04-19 Aiming high: Shigeru Obayashi is innovating human flight 2017-01-17 Exploring the Earth and its neighbors 2016-11-04 YUI Project - Ties that Bind and Save Lives 2016-10-12 Sea Change 2016-08-22 Brain training turns back your cognitive clock 2016-07-11 Forcing liquids into a squeeze 2016-06-03 Brain buster: Noriko Osumi is uncovering the links between genetics and brain development 2016-05-26 Sparking the next revolution in data science 2016-05-10 Taking memory for a spin 2016-04-11 Fueling the hydrogen revolution 2016-01-12 A Planner by Design 2015-10-29 Robo Rescue! 2015-10-01 Understanding Muscles 2015-08-31 Some sense of touch 2015-07-31 Surrogacy and the Law Page Top About Tohoku University Academics Admissions Research Campus Life News Events International Affairs Students Alumni Promotional Videos Subscribe to our Newsletter Map & Directions Contact Tohoku University Jobs & Vacancies Emergency Information Site Map Media Enquiries Parent & Family Support Public Facilities Contact Tohoku University