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× {{flash.message}} Toggle navigation Toggle navigation 日本語 | English 新規登録ログイン 細川 まゆ子 ホソカワ マユコ  (Mayuko Hosokawa) 更新日: 01/31 ホーム研究キーワード研究分野学歴論文MISC書籍等出版物講演・口頭発表等担当経験のある科目(授業)所属学協会Works(作品等)共同研究・競争的資金等の研究課題 論文 査読有り 2016年3月 Prenatal exposure to bisphenol A impacts neuronal morphology in the hippocampal CA1 region in developing and aged mice ARCHIVES OF TOXICOLOGY Eiki Kimura, Chieri Matsuyoshi, Wataru Miyazaki, Seico Benner, Mayuko Hosokawa, Kazuhito Yokoyama, Masaki Kakeyama, Chiharu Tohyama 巻 90 号 3 開始ページ 691 終了ページ 700 記述言語 英語 掲載種別 研究論文（学術雑誌） DOI 10.1007/s00204-015-1485-x 出版者・発行元 SPRINGER HEIDELBERG Bisphenol A (BPA), a widely used raw component of polycarbonate plastics and epoxy resins, has been reported to induce developmental neurotoxicity in offspring born to dams exposed to low doses of BPA; however, the toxicity mechanism remains elusive. To study the effects of in utero BPA exposure on neuronal morphology, we studied spine density and dendritic growth in the hippocampal CA1 of aged mice and developing mice prenatally exposed to low doses of BPA. Pregnant mice were orally administered BPA at a low dose of 0, 40, or 400 mu g/kg body weight/day on gestational days 8.5-17.5/18.5. Mouse progenies were euthanized at 3 weeks or 14 months, and their brains were analyzed for dendritic arborization of GFP-expressing neurons or spine densities of Golgi-stained neurons in the hippocampal CA1. Regardless of the dose, in utero BPA exposure reduced spine densities in the hippocampal CA1 of the 14-month-old mice. In the developing brain from the 3-week-old mice born to dams exposed to BPA at a dose of 400 mu g/kg body weight/day, overall length and branching number of basal dendrites but not apical dendrites were decreased. In utero low doses of BPA exposure disrupts hippocampal CA1 neuronal morphology during development, and this disruption is believed to persist in adulthood. リンク情報 DOIhttps://doi.org/10.1007/s00204-015-1485-xPubMedhttps://www.ncbi.nlm.nih.gov/pubmed/25804199Web of Sciencehttps://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000370343000015&DestApp=WOS_CPL ID情報 DOI : 10.1007/s00204-015-1485-xISSN : 0340-5761eISSN : 1432-0738PubMed ID : 25804199Web of Science ID : WOS:000370343000015 エクスポート BibTeX RIS 論文リストへ メニュー マイポータル 研究ブログ資料公開 共著者の一覧 まだ共著者が1人も登録されていません。 {{coauthor.Related.name_str}} {{coauthor.Related.last_modified}} 更新 limit"> もっとみる 2017 researchmap 利用規約