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杏林大学病院 看護専門学校--> English Chinese 杏林大学トップページ 交通アクセス お問い合わせ 資料請求 サイトマップ 杏林大学 文字サイズを大きく 標準の文字サイズ 文字サイズを小さく 杏林大学について 学部・大学院 受験生サイト 就職・キャリア 留学・国際交流 キャンパスライフ・施設 研究・社会活動 大学ホーム医学研究科教育・研究指導教員紹介： 医学研究科 医学研究科トップページへ戻る サイトマップ 教員紹介：福原　浩 氏名  福原　浩 フクハラ　ヒロシ FUKUHARA, Hiroshi 職位 教授 学内の役職・委員等 教授 所属教室 泌尿器科学教室 専攻・専門分野　（大学院） 21 医学専攻 泌尿器科学分野（新課程） 外科系専攻 泌尿器科学分野（旧課程） 担当科目（学部） 泌尿器科学 担当科目（大学院） 泌尿器科学演習、泌尿器腫瘍学 専門分野 泌尿器腫瘍学、腹腔鏡・ロボット手術、ウイルス療法 研究テーマ 1.がん治療用ウイルスを用いたウイルス療法 2.泌尿器癌におけるがんゲノム医療 略歴 1995年　東京大学医学部医学科卒業 2001年　米国ハーバード大学(MGH病院) フェロー 2006年　東京大学医学部泌尿器科　講師 2014年　東京大学大学院医学系研究科泌尿器外科　准教授 2018年　杏林大学医学部泌尿器科　教授 所有する学位 博士（医学） 指導医・専門医・認定医、その他の資格等 日本泌尿器科学会：専門医・指導医、泌尿器腹腔鏡技術認定医、日本内視鏡外科学会技術認定医、がん治療認定医、腹腔鏡下小切開手術施設基準医認定医、泌尿器ロボット支援手術プロクター認定医、日本遺伝子細胞治療学会認定医 論文・著書等を含む主要研究業績 2024年 1. Taguchi S, Sugawara K, Gonoi W, Hanaoka S, Shiomi S, Kishitani K, Uemura Y, Akamatsu N, Inui S, Tanaka K, Yagi K, Kawai T, Nakagawa T, Fukuhara H, Abe O, Seto Y, Gonzalez MC, Prado CM, Kume H. The importance of ethnic-specific cut-offs of low muscle mass for survival prediction in oncology. Clin Nutr. 43, 134-141, 2024. 2. Yamada Y, Fujii Y, Kakutani S, Kimura N, Sugimoto K, Hakozaki Y, Sugihara T, Takeshima Y, Kawai T, Nakamura M, Kamei J, Taguchi S, Akiyama Y, Sato Y, Yamada D, Urabe F, Miyazaki H, Enomoto Y, Fukuhara H, Nakagawa T, Fujimura T, Kume H. Development of risk-score model in patients with negative surgical margin after robot-assisted radical prostatectomy. Sci Rep. 14, 7607, 2024. 3. Takeuchi T, Hattori-Kato M, Okuno Y, Nomiya A, Fukuhara H, Zaitsu M, Azuma T. A Genome-Wide Association Study of Prostate Cancer Susceptibility Using Occupational and Environmental Factors as Confounding Factors. Cureus. 16, e52926, 2024. 4. Noda M, Taguchi S, Shiraishi K, Fujimura T, Naito A, Kawai T, Kamei J, Akiyama Y, Yamada Y, Sato Y, Yamada D, Nakagawa T, Yamashita H, Nakagawa K, Abe O, Fukuhara H, Kume H. Six-year outcomes of robot-assisted radical prostatectomy versus volumetric modulated arc therapy for localized prostate cancer: A propensity score-matched analysis. Strahlenther Onkol. 2024, in press 2023年 5. Fukuhara H, Sato YT, Hou J, Iwai M, Todo T. Fusion peptide is superior to co-expressing subunits for arming oncolytic herpes virus with interleukin 12. Commun Med (Lond). 3, 40, 2023. 6. Kinjo M, Masuda K, Nakamura Y, Miyakawa J, Tambo M, Fukuhara H. Comparison of mirabegron and vibegron in women with treatment-naive overactive bladder: a randomized controlled study. Urology 175, 67-73, 2023. 7. Kinjo M, Masuda K, Nakamura Y, Taguchi S, Tambo M, Fukuhara H. Does metabolic syndrome influence the efficacy of mirabegron treatment in female patients with overactive bladder? Int Urogynecol J. 34, 853-859, 2023. 8. Kitamura J, Tambo M, Nishijima A, Masuda K, Miyakawa J, Nakamura Y, Fujiwara M, Kishida T, Ito H, Fukuhara H. Surgical resection in patient with teratoma with somatic-type malignancy transformed into rhabdomyosarcoma resulted in long-term survival. IJU Case Rep., 6, 302-305, 2023. 9. Iwaki T, Akiyama Y, Nosato H, Kinjo M, Niimi A, Taguchi S, Yamada Y, Sato Y, Kawai T, Yamada D, Sakanashi H, Kume H, Homma Y, Fukuhara H. Deep Learning Models for Cystoscopic Recognition of Hunner Lesion in Interstitial Cystitis. Eur Urol Open Sci. 49, 44-50, 2023. 10. Hattori-Kato M, Okuno Y, Zaitsu M, Fukuhara H, Nomiya A, Mikami K, Takeuchi T. Hypomethylation of a CpG Site in the CpG Island of the Aquaporin 1 Gene May Be Involved in the Formation of Adult-Onset Non-communicating Hydrocele Testis. Cureus. 15, e47651, 2023. 11. Taguchi S, Kawai T, Ambe Y, Kishitani K, Sugimoto K, Miyakawa J, Nakamura Y, Noda M, Kaneko T, Kamei J, Obinata D, Yamaguchi K, Kakutani S, Furuya Y, Sato Y, Uemura Y, Akiyama Y, Yamada Y, Sato Y, Yamada D, Enomoto Y, Nishimatsu H, Fujimura T, Fukuhara H, Nakagawa T, Takahashi S, Kume H. Enfortumab vedotin versus platinum rechallenge in post-platinum, post-pembrolizumab advanced urothelial carcinoma: A multicenter propensity score-matched study. Int J Urol., 2023, in press. 12. Taguchi S, Kawai T, Buti S, Bersanelli M, Uemura Y, Kishitani K, Miyakawa J, Sugimoto K, Nakamura Y, Niimi F, Kaneko T, Kamei J, Obinata D, Yamaguchi K, Kakutani S, Kanazawa K, Sugihara Y, Tokunaga M, Akiyama Y, Yamada Y, Sato Y, Yamada D, Enomoto Y, Nishimatsu H, Fujimura T, Fukuhara H, Nakagawa T, Takahashi S, Kume H. Validation of a drug-based score in advanced urothelial carcinoma treated with pembrolizumab. Immunotherapy, 15, 827-837, 2023. 13. Okuno Y, Hori M, Hattori-Kato M, Fukuhara H, Nomiya A, Mikami K, Takeuchi T. Structural Analysis of the Colony-Stimulating Factor 3 Gene of Granulocyte Colony-Stimulating Factor-Producing Urothelial Cancer. Cureus, 15, e43981, 2023. 14. Ochiai K, Mochida Y, Nagase T, Fukuhara H, Ymaguchi Y, Nagase M. Upregulation of piezo2 in the mesangial, renin, and perivascular mesenchymal cells of the kidney of Dahl salt-sensitive hypertensive rats and its reversal by esaxerenone. Hypertens Res. 46, 1234-1246, 2023. 15. Tohi Y, Ishikawa R, Kato T, Miyakawa J, Matsumoto R, Mori K, Mitsuzuka K, Inokuchi J, Matsumura M, Shiga K, Naito H, Kohjimoto Y, Kawamura N, Inoue M, Akamatsu S, Terada N, Miyazawa Y, Narita S, Haba R, Sugimoto M. Increasing age predicts adverse pathology including intraductal carcinoma of the prostate and cribriform patterns in deferred radical prostatectomy after upfront active surveillance for Gleason grade group 1 prostate cancer: analysis of prospective observational study cohort. Jpn J Clin Oncol., 53, 984-990, 2023. 16. Yamada Y, Nakagawa T, Miyakawa J, Kawai T, Taguchi S, Tabata M, Kaneko T, Ishikawa A, Miyazaki H, Kondo Y, Matsumoto A, Naito A, Hikatsu M, Fujii Y, Akiyama Y, Yamada Y, Sato Y, Nomiya A, Yamada D, Murata T, Suzuki M, Enomoto Y, Nishimatsu H, Takeuchi T, Tanaka Y, Kume H. Subclassification of pT3 upper tract urothelial carcinoma: a multicenter retrospective study. World J Urol., 41, 767-776, 2023. 17. Tohi Y, Ishikawa R, Kato T, Miyakawa J, Matsumoto R, Mori K, Mitsuzuka K, Inokuchi J, Matsumura M, Shiga K, Naito H, Kohjimoto Y, Kawamura N, Inoue M, Kinoshita H, Hashimoto K, Goto K, Haba R, Kakehi Y, Sugimoto M. Clinical outcomes of intraductal carcinoma or cribriform in radical prostatectomy specimens of men opting for active surveillance: data from the PRIAS-JAPAN study. Int J Clin Oncol., 28, 299-305, 2023. 18. Takeshima Y, Yamada Y, Takemura K, Kimura N, Hakozaki Y, Miyakawa J, Taguchi S, Akiyama Y, Sato Y, Kawai T, Yamada D, Fujimura T, Kume H. The association between the parameters of uroflowmetry and lower urinary tract symptoms in prostate cancer patients after robot-assisted radical prostatectomy. PLoS One, 17, e0275069, 2023. 19. Akiyama Y, Harada K, Miyakawa J, Kreder KJ, O'Donnell MA, Daichi M, Katoh H, Hori M, Owari K, Futami K, Ishikawa S, Ushiku T, Kume H, Homma Y, Luo Y. Th1/17 polarization and potential treatment by an anti-interferon-γ DNA aptamer in Hunner-type interstitial cystitis. iScience, 26, 108262, 2023. 20. Akiyama Y, Niimi A, Nomiya A, Taguchi S, Yamada Y, Sato Y, Yamada D, Maeda D, Ushiku T, Kume H, Homma Y. Efficacy and Safety of Low-dose Oral Prednisolone for Patients with Refractory Hunner-type Interstitial Cystitis. Eur Urol Open Sci, 56, 1-8, 2023. 21. Akiyama Y, Niimi A, Nomiya A, Taguchi S, Yamada Y, Sato Y, Kawai T, Yamada D, Kume H, Homma Y. Efficacy and safety of intravesical dimethyl sulfoxide treatment for patients with refractory Hunner-type interstitial cystitis: Real-world data postofficial approval in Japan. Int J Urol. 2023, in press. 22. Akiyama Y, Sonehara K, Maeda D, Katoh H, Naito T, Yamamoto K; Biobank Japan Project; Morisaki T, Ishikawa S, Ushiku T, Kume H, Homma Y, Okada Y. Genome-wide association study identifies risk loci within the major histocompatibility complex region for Hunner-type interstitial cystitis. Cell Rep Med, 4, 101114, 2023. 23. Seito T, Ishikawa A, Tsuru I, Hikatsu M, Ishibsahi Y, Bae Y, Homma Y. Bladder Preservation After Bilateral Kidney Loss and Bladder Cancer After Renal Transplantation: A Case Report. Transplant Proc. 55, 660-663, 2023. 24. Kamei J, Sugihara T, Yasunaga H, Matsui H, Sasabuchi Y, Fujimura T, Homma Y, Kume H. Impact of early ureteral drainage on mortality in obstructive pyelonephritis with urolithiasis: an analysis of the Japanese National Database. J Urol., 41, 1365-1371, 2023. 2022年 25. Sugimoto K, Taguchi S, Kishitani K, Kawai T, Masuda K, Nakamura Y, Kinjo M, Tambo M, Miyakawa J, Akiyama Y, Yamada Y, Sato Y, Yamada D, Nakagawa T, Fukuhara H, Kume H. Comparison of full-dose gemcitabine/cisplatin, dose-reduced gemcitabine/cisplatin, and gemcitabine/carboplatin in real-world patients with advanced urothelial carcinoma. BMC Urol. 22, 177, 2022. 26. Taguchi S, Kawai T, Nakagawa T, Miyakawa J, Kishitani K, Sugimoto K, Nakamura Y, Kamei J, Obinata D, Yamaguchi K, Kaneko T, Yoshida K, Yamamoto S, Kakutani S, Kanazawa K, Sugihara Y, Tokunaga M, Matsumoto A, Uemura Y, Akiyama Y, Yamada Y, Sato Y, Yamada D, Enomoto Y, Nishimatsu H, Ishikawa A, Tanaka Y, Nagase Y, Fujimura T, Fukuhara H, Takahashi S, Kume H. Improved survival in real-world patients with advanced urothelial carcinoma: A multicenter propensity score-matched cohort study comparing a period before the introduction of pembrolizumab (2003-2011) and a more recent period (2016-2020). Int J Urol. 29, 1462-1469, 2022. 27. Taguchi S, Watanabe M, Tambo M, Machida H, Yokoyama K, Fukuhara H. Proposal for a New Vesical Imaging-Reporting and Data System (VI-RADS)-Based Algorithm for the Management of Bladder Cancer: A Paradigm Shift From the Current Transurethral Resection of Bladder Tumor (TURBT)-Dependent Practice. Clin Genitourin Cancer. 20, e291-e295, 2022. 28. Nakamura Y, Taguchi S, Kinjo M, Tanbo M, Okegawa T, Fukuhara H. Adrenal metastasis in nivolumab-treated renal cell carcinoma: A unique entity as a sanctuary site. Int. J Urol. 29, 597-599, 2022. 29. Kinjo M, Tanba M, Masuda K, Nakamura Y, Tanbo M, Fukuhara H. Comparison of effectiveness between modified transvaginal mesh surgery and vaginal pessary treatment in patients with symptomatic pelvic organ prolapse. Low Urin Tract Symptoms. 14, 64-71, 2022. 30. Shishido T, Okegawa T, Hayashi K, Masuda K, Taguchi S, Nakamura Y, Tambo M, Fukuhara H. Laparoscopic retroperitoneal lymph node dissection versus open retroperitoneal lymph node dissection for testicular cancer: A comparison of clinical and perioperative outcomes. Asian J Urol, 9, 119-124, 2022. 31. Kitahama K, Yoshiike S, Nagahama K, Ninomiya N, Okegawa T, Fukuhara H, Nabeshima K, Oka T, Shibahara J. Well-differentiated papillary mesothelial tumor presenting as an encysted hydrocele of the spermatic cord. Pathol Int. 72, 352-354, 2022. 32. Watanabe M, Taguchi S, Machida H, Tambo M, Takeshita Y, Kariyasu T, Fukushima K, Shimizu Y, Okegawa T, Fukuhara H, Yokoyama K. Clinical validity of non-contrast-enhanced VI-RADS: prospective study using 3-T MRI with high-gradient magnetic field. Eur Radiol. 32, 7513-7521, 2022. 33. Mochida Y, Ochiai K, Nagase T, Nonomura K, Akimoto Y, Fukuhara H, Sakai T, Matsumura G, Yamaguchi Y, Nagase M. Piezo2 expression and its alteration by mechanical forces in mouse mesangial cells and renin-producing cells. Sci Rep. 12, 4197, 2022. 34. Kato T, Yokomizo A, Matsumoto R, Tohi Y, Miyakawa J, Mitsuzuka K, Sasaki H, Inokuchi J, Matsumura M, Sakamoto S, Kinoshita H, Fukuhara H, Kamiya N, Kimura R, Nitta M, Okuno H, Akakura K, Kakehi Y, Sugimoto M. Comparison of the medical costs between active surveillance and other treatments for early prostate cancer in Japan using data from the PRIAS-JAPAN study. Int J Urol. 29, 1271-1278, 2022. 35. Kawai T, Taguchi S, Nakagawa T, Kamei J, Nakamura Y, Obinata D, Yamaguchi K, Kaneko T, Kakutani S, Tokunaga M, Uemura Y, Sato Y, Enomoto Y, Nishimatsu H, Fujimura T, Fukuhara H, Takahashi S, Kume H. Impact of immune-related adverse events on the therapeutic efficacy of pembrolizumab in urothelial carcinoma: a multicenter retrospective study using time-dependent analysis. J Immunother Cancer. 10, e003965, 2022. 36. Tohi Y, Kato T, Miyakawa J, Matsumoto R, Sasaki H, Mitsuzuka K, Inokuchi J, Matsumura M, Yokomizo A, Kinoshita H, Hara I, Kawamura N, Hashimoto K, Inoue M, Teishima J, Kanno H, Fukuhara H, Maruyama S, Sakamoto S, Saito T, Kakehi Y, Sugimoto M. Impact of adherence to criteria on oncological outcomes of radical prostatectomy in patients opting for active surveillance: data from the PRIAS-JAPAN study. Jpn J Clin Oncol. 52, 1056-1061, 2022. 37. Yokomizo A, Yonese J, Egawa S, Fukuhara H, Uemura H, Nishimura K, Nagata M, Saito A, Lee T, Yamaguchi S, Nonomura N. Real-world use of enzalutamide in men with nonmetastatic castration-resistant prostate cancer in Japan. Int J Clin Oncol. 27, 418-426, 2022. 38. Tohi Y, Kato T, Nakamura M, Matsumoto R, Sasaki H, Mitsuzuka K, Inokuchi J, Hashine K, Yokomizo A, Naito H, Hara I, Kawamura N, Inoue M, Fukuhara H, Maruyama S, Sakamoto S, Saito T, Egawa S, Kakehi Y, Sugimoto M. Deferred radical prostatectomy in patients who initially elected for active surveillance: a multi-institutional, prospective, observational cohort of the PRIAS-JAPAN study. Int J Clin Oncol. 27, 194-201, 2022. 39. Oshina T, Taguchi S, Miyakawa J, Akiyama Y, Sato Y, Kawai T, Fukuhara H, Nakagawa T, Kume H. Clinicopathological features and oncological outcomes of urothelial carcinoma involving the ureterovesical junction. Jpn J Clin Oncol. 52, 65-72, 2022. 40. Tohi Y, Kato T, Yokomizo A, Mitsuzuka K, Tomida R, Inokuchi J, Matsumoto R, Saito T, Sasaki H, Inoue K, Kinoshita H, Fukuhara H, Maruyama S, Sakamoto S, Tanikawa T, Egawa S, Ichikura H, Abe T, Nakamura M, Kakehi Y, Sugimoto M. Impact of health-related quality of life on repeat protocol biopsy compliance on active surveillance for favorable prostate cancer; results from a prospective cohort in the Prostate Cancer Research International: Active Surveillance (PRIAS)-JAPAN study. Urol Oncol. 40, 56.e.9-e15, 2022. 41. Kato T, Hirama H, Mitsuzuka K, Maruyama S, Sasaki H, Saito T, Matsumoto R, Sakamoto S, Sakai Y, Fukuhara H, Naya Y, Tsukino H, Hara I, Ogawa O, Hashine K, Fumimasa F, Yokomizo A, Tohi Y, Kakehi Y, Sugimoto M. Reclassification prediction of first-year protocol biopsy on active surveillance of prostate cancer by p2PSA-related parameters: from PRIAS-JAPAN. Prostate Cancer Prostatic Dis. 25, 666-671, 2022. Kimura N, Yamada Y, Takeshima Y, Otsuka M, Akamatsu N, Hakozaki Y, Miyakawa J, Sato Y, Akiyama Y, Yamada D, Fujimura T, Kume H. The 'prostate-muscle index': a simple pelvic cavity measurement predicting estimated blood loss and console time in robot-assisted radical prostatectomy. Sci Rep., 12, 11945, 2022. 42. Teshima T, Kobayashi Y, Kawai T, Kushihara Y, Nagaoka K, Miyakawa J, Akiyama Y, Yamada Y, Sato Y, Yamada D, Tanaka N, Tsunoda T, Kume H, Kakimi K. Principal component analysis of early immune cell dynamics during pembrolizumab treatment of advanced urothelial carcinoma..Oncol Lett., 24, 265, 2022. 43. Akiyama Y, Miyakawa J, O'Donnell MA, Kreder KJ, Luo Y, Maeda D, Ushiku T, Kume H, Homma Y. Overexpression of HIF1α in Hunner Lesions of Interstitial Cystitis: Pathophysiological Implications. J Urol., 207, 635-646, 2022. 2021年 44. Fukuhara H, Takeshima Y, Todo T. Triple-mutated oncolytic herpes virus for treating both fast- and slow-growing tumor. Cancer Sci, 112, 3293-3301, 2021. 45. Higashihara E, Nutahara K, Itoh M, Okegawa T, Tambo M, Yamaguchi T, Nakamura Y, Taguchi S, Kaname S, Yokoyama K, Yoshioka T, Fukuhara H. Long-Term Outcomes of Longitudinal Efficacy Study With Tolvaptan in ADPKD. Kidney Int Rep. 7, 270-281, 2021. 46. Kitamura J, Taguchi S, Okegawa T, Honda K, Kii T, Tomida Y, Matsumoto R, Ninomiya N, Masuda K, Nakamura Y, Yamaguchi T, Kinjo M, Tambo M, Isomura A, Hayashi A, Kamma H, Higashihara E, Shibahara J, Fukuhara H. Genomic analysis of circulating tumor cells in adenosquamous carcinoma of the prostate: a case report. BMC Med Genomics. 14, 217, 2021 47. Taguchi S, Kawai T, Nakagawa T, Nakamura Y, Kamei J, Obinata D, Yamaguchi K, Kaneko T, Kakutani S, Tokunaga M, Uemura Y, Sato Y, Fujimura T, Fukuhara H, Enomoto Y, Nishimatsu H, Takahashi S, Kume H. Prognostic significance of the albumin-to-globulin ratio for advanced urothelial carcinoma treated with pembrolizumab: a multicenter retrospective study. Sci Rep. 11, 15623, 2021. 48. Shigemori K, Higashihara E, Itoh M, Yoshida H, Yamamoto K, Nutahara K, Shiokawa Y, Kaname S, Tambo M, Yamaguchi T, Taguchi S, Yoshioka T, Yokoyama K, Fukuhara H. PKD1- associated Arachnoid Cysts in Autosomal Dominant Polycystic Kidney Disease. J Stroke Cerebrovasc Dis. 30, 105943, 2021. 49. Kii T, Taguchi S, Nagahama K, Shimoyamada H, Honda K, Tomida Y, Matsumoto R, Kitamura J, Ninomiya N, Masuda K, Nakamura Y, Yamaguchi T, Kinjo M, Tambo M, Okegawa T, Higashihara E, Shibahara J, Fukuhara H. Pigmented median raphe cyst of the penis that developed after middle age without infection or trauma history. IJU Case Reports, 4, 172-175, 2021. 50. Taguchi S, Morikawa T, Shibahara J, Fukuhara H. Prognostic significance of tertiary Gleason pattern in the contemporary era of Gleason grade grouping: A narrative review. Int J Urol. 28, 614-621, 2021. 51. Taguchi S, Nakagawa T, Uemura Y, Akamatsu N, Gonoi W, Naito A, Kawai T, Kume H, Fukuhara H. Comparison of Major Definitions of Sarcopenia Based on the Skeletal Muscle Index in Patients with Urothelial Carcinoma. Future Oncology, 17, 197-203, 2021. 52. Taguchi S, Tambo M, Watanabe M, Machida H, Kariyasu T, Fukushima K, Shimizu Y, Okegawa T, Yokoyama K, Fukuhara H. Prospective validation of Vesical Imaging-Reporting and Data System (VI-RADS) using a next-generation magnetic resonance imaging scanner: Is denoising deep learning reconstruction useful? J Urol, 205. 686-692, 2021. 53. Kinjo M, Nakamura Y, Taguchi S, Yamaguchi T, Tambo M, Okegawa T, Fukuhara H. Sex differences in prevalence and patient behavior regarding lower urinary tract symptoms among Japanese medical checkup examinees. Urology, 151, 24-30, 2021. 54. Uchihashi T, Nakahara H, Fukuhara H, Iwai M, Ito H, Sugauchi A, Tanaka M, Kogo M, Todo T. Oncolytic herpes virus G47∆ injected into tongue cancer swiftly traffics in lymphatics and suppresses metastasis, Mol Ther Oncolytics. 22, 388-398, 2021. 55. Matsumura S, Nakamori M, Tsuji T, Kato T, Nakamura M, Ojima T, Fukuhara H, Ino Y, Todo T, Yamaue H. Oncolytic virotherapy with SOCS3 enhances viral replicative potency and oncolysis for gastric cancer. Oncotarget, 12, 344-354, 2021. 56. Inoue T, Okada S, Hamamoto S, Miura H, Matsuzaki J, Tambo M, Fukuhara H, Fujisawa M, Matsuda T, Nutahara K. Evaluation of flexible ureteroscope with an omni-directional bending tip, using a JOYSTICK unit (URF-Y0016); an ex-vivo study. World Journal of Urology, 39, 209-215, 2021. 57. Mizuno K, Sumiyoshi T, Okegawa T, Terada N, Ishitoya S, Miyazaki Y, Kojima T, Katayama H, Fujimoto N, Hatakeyama S, Shiota M, Yoshimura K, Matsui Y, Narita S, Matsumoto H, Kurahashi R, Kanno H, Ito K, Kimura H, Kamiyama Y, Sunada T, Goto T, Kobayashi T, Yamada H, Tsuchiya N, Kamba T, Matsuyama H, Habuchi T, Eto M, Ohyama C, Ito A, Nishiyama H, Okuno H, Kamoto T, Fujimoto A, Ogawa O, Akamatsu S. Clinical Impact of Detecting Low-Frequency Variants in Cell-Free DNA on Treatment of Castration-Resistant Prostate Cancer. Clin Cancer Res. 27, 6164-6173, 2021. 2020年 58. Higashihara E, Horie S, Muto S, Kawano H, Tanbo M, Yamaguchi T, Taguchi S, Kaname S, Yokoyama K, Yoshioka T, Fukukawa T, Fukuhara H. Imaging Identification of Rapidly Progressing Autosomal Dominant Polycystic Kidney Disease: Simple Eligibility Criterion for Tolvaptan. American Journal of Nephrology, 51, 891-890, 2020. 59. Kinjo M, Masuda K, Nakamura Y, Taguchi S, Tambo M, Okegawa T, Fukuhara H. Effects on depression and anxiety after mid-urethral sling surgery for female stress urinary incontinence. Research and Reports in Urology, 12, 495-501, 2020. 60. Higashihara E, Fukuhara H, Ouyang J, Lee J, Nutahara K, Tanbo M, Yamaguchi T, Taguchi S, Muto S, Kanayama S, Miyazaki I, Horie S. Estimation of changes in kidney volume growth rate in autosomal dominant polycystic kidney disease. Kidney Int Rep., 5, 1459-1471, 2020. 61. Omura S, Taguchi S, Miyagawa S, Matsumoto R, Samejima M, Ninomiya N, Masuda K, Nakamura Y, Yamaguchi T, Kinjo M, Tambo M, Okegawa T, Higashihara E, Fukuhara H. Prognostic significance of the albumin-to-globulin ratio for upper tract urothelial carcinoma. BMC Urology, 20, 133, 2020. 62. Naito A, Taguchi S, Suzuki M, Kawai T, Uchida K, Fujimura T, Fukuhara H, Kume H. Transient acute kidney injury observed immediately after robot-assisted radical prostatectomy but not after open radical prostatectomy. Molecular and Clinical Oncology, 13, 18, 2020. 63. Taguchi S, Shiraishi K, Fukuhara H. Updated evidence on oncological outcomes of surgery versus external beam radiotherapy for localized prostate cancer. Jpn J Clin Oncol. 50, 963-969, 2020. 64. Taguchi S, Uemura Y, Fujimura T, Morikawa T, Naito A, Kawai T, Suzuki M, Kume H, Fukuhara H. Quantification of the individual risk of each Gleason pattern, including tertiary Gleason pattern 5, after radical prostatectomy: development of the modified Gleason grade grouping (mGGG) model. BMC Cancer, 20, 371, 2020. 65. Okegawa T, Omura S, Samejima M, Ninomiya N, Taguchi S, Nakamura Y, Yamaguchi T, Tambo M, Fukuhara H. Laparoscopic radical prostatectomy versus robot-assisted radical prostatectomy: comparison of oncological outcomes at a single center. Prostate Int. 8, 16-21, 2020. 66. Tambo M, Taguchi S, Nakamura Y, Okegawa T, Fukuhara H. Presepsin and procalcitonin as predictors of sepsis based on the new Sepsis-3 definition in obstructive pyelonephritis. BMC Urol. 20, 23, 2020. 67. Masuda K, Aizawa N, Watanabe D, Okegawa T, Kume H, Igawa Y, Fukuhara H. Pathophysiological changes of the lower urinary tract behind voiding dysfunction in streptozotocin-induced long-term diabetic rats. Scientific Reports. 10, 4182, 2020. 68. Kakutani S, Asamoto M, Araki F, Chen YN, Shinokawa M, Okagami Y, Ohata T, Taguchi S, Yamada Y, Takeshima Y, Kume H, Yamada Y, Aihara M, Ito N, Fukuhara H. Prospective evaluation of visual function in patients with ocular diseases after robotic-assisted laparoscopic prostatectomy. Int J Urol. 27, 307-313, 2020. 69. Tambo M, Inoue T, Miura H, Matsuzaki J, Nutahara K, Hamamoto S, Okada S, Fukuhara H, Fujisawa M, Matsuda T. A novel flexible ureteroscope with omnidirectional bending tip using joystick-type control unit (URF-Y0016): initial validation study in bench models. J Endourol. 34, 676-681, 2020. 70. Shimizu T, Yamaguchi K, Yamamoto M, Kurioka R, Kino Y, Matsunaga W, Nakao S, Fukuhara H, Tanaka A, Gotoh A, Mabuchi M. Identification of HUHS190, a human naftopidil metabolite, as a novel anti-bladder cancer drug. Bioorganic & Medicinal Chemistry Letter 30, 126744, 2020. 71. Yoshida A, Arai Y, Hama N, Chikuta H, Bando Y, Nakano S, Kobayashi E, Shibahara J, Fukuhara H, Komiyama M, Watanabe SI, Tamura K, Kawai A, Shibata T, Expanding the clinicopathologic and molecular spectrum of BCOR-associated sarcomas in adults. Histopathology 76, 509-520, 2020. 72. Taguchi S, Nakagawa T, Fukuhara H. Inconsistencies in currently used definitions of sarcopenia in oncology. Annals of Oncology 31, 318-319, 2020. 2019年 73. Nakato R, Wada Y, Nakaki R, Nagae G, Katou Y, Tsutsumi S, Nakajima N, Fukuhara H, Iguchi A, Kohro T, Kanki Y, Saito Y, Kobayashi M, Izumi-Taguchi A, Osato N, Tatsuno K, Kamio A, Hayashi-Takanaka Y, Wada H, Ohta S, Aikawa M, Nakajima H, Nakamura M, McGee RC, Heppner KW, Kawakatsu T, Genno M, Yanase H, Kume H, Senbonmatsu T, Homma Y, Nishimura S, Mitsuyama T, Aburatani H, Kimura H, Shirahige K. Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells. Epigenetics Chromatin. 12, 77, 2019. 74. Taguchi S, Shiraishi K, Fujimura T, Naito A, Kawai T, Nakagawa K, Abe O, Kume H, Fukuhara H*. Robot-assisted radical prostatectomy versus volumetric modulated arc therapy: Comparison of front-line therapies for localized prostate cancer. Radiother Oncol. 140, 62-66, 2019. 75. Watanabe S, Hayashi K, Toh K, Kim HJ, Liu X, Chaya H, Fukushima S, Katsushima K, Kondo Y, Uchida S, Ogura S, Nomoto T, Takemoto H, Cabral H, Kinoh H, Tanaka HY, Kano MR, Matsumoto Y, Fukuhara H, Uchida S, Nangaku M, Osada K, Nishiyama N, Miyata K, Kataoka K. In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers. Nat Commun. 10, 1894, 2019. 76. Fujimura T, Igawa Y, Aizawa N, Niimi A, Yamada Y, Sugihara T, Kamei J, Sato Y, Matsunaga A, Yoshida M, Shinoda Y, Fukuhara H, Nakagawa T, Homma Y, Kume H. Longitudinal change of comprehensive lower urinary tract symptoms and various types of urinary incontinence during robot-assisted radical prostatectomy. Neurourol Urodyn 38, 1067-1075, 2019. 77. Akiyama Y, Daichi M, Katoh H, Morikawa T, Niimi A, Nomiya A, Sato Y, Kawai T, Goto A, Fujimura T, Fukuhara H, Nakagawa T, Igawa Y, Ishikawa S, Fukayama M, Kume H, Homma Y. Molecular Taxonomy of Interstitial Cystitis/Bladder Pain Syndrome Based on Whole Transcriptome Profiling by Next-Generation RNA Sequencing of Bladder Mucosal Biopsies. J Urol. 202, 290-300, 2019. 78. Kinjo M, Yamaguchi T, Tambo M, Okegawa T, Fukuhara H. Effects of Mirabegron on Anxiety and Depression in Female Patients with Overactive Bladder. Urol Int. 102, 331-335, 2019. 79. Taguchi S, Fukuhara H*, Todo T. Oncolytic virus therapy in Japan: progress in clinical trials and future perspectives.Jpn J Clin Oncol. 49, 201-209, 2019. 80. Samejima M, Taguchi S, Miyagawa S, Matsumoto R, Omura S, Ninomiya N, Nakamura Y, Yamaguchi T, Kinjo M, Tambo M, Okegawa T, Koba T, Matsuki R, Jimbo I, Motoyasu A, Tsumura T, Shimoyamada H, Shibahara J, Sakamoto Y, Fukuhara H. Acute hypotension induced by suction of cystic fluid containing extremely high concentrations of catecholamines during resection of giant pheochromocytoma. IJU Case Rep, 2, 218-220, 2019. 81. Taguchi S, Nakagawa T, Fukuhara H. Re: Jürgen E. Gschwend, Matthias M. Heck, Jan Lehmann, et al. Extended Versus Limited Lymph Node Dissection in Bladder Cancer Patients Undergoing Radical Cystectomy: Survival Results from a Prospective, Randomized Trial. Eur Urol 2019. Eur Urol, S0302-2838, 30345-30348, 2019. 82. Gansevoort RT, van Gastel MDA, Chapman AB, Blais JD, Czerwiec FS, Higashihara E, Lee J, Ouyang J, Perrone RD, Stade K, Torres VE, Devuyst O; TEMPO 3:4 Investigators. Plasma copeptin levels predict disease progression and tolvaptan efficacy in autosomal dominant polycystic kidney disease. Kidney Int. 96: 159-169. 2019 83. Higashihara E，Yamamoto K，Kaname S，Okegawa T，Tanbo M，Yamaguchi T，Shigemori K，Miyazaki I，Yokoyama K，Nutahara K：Age- and height-adjusted total kidney volume growth rate in autosomal dominant polycystic kidney diseases. Clin Exp Nephrol. 23, 100-111, 2019. 84. Buti S，Karakiewicz PI，Bersanelli M，Capitanio U，Tian Z，Cortellini A，Taguchi S, Briganti A，Montorsi F，Leonardi F，Bandini M. Validation of the Grade, Age, Nodes and Tumor (GRANT) score within the Surveillance Epidemiology and End Results (SEER) database: A new tool to predict survival in surgically treated renal cell carcinoma patients. Sci Rep. 9, 13218, 2019. 85. Fujisaki A, Kinjo M, Shimoinaba M, Honda S, Yoshimura Y. An evaluation of the impact of post-hysterectomy vesicovaginal fistula repair on the mental health of patients in a developed country. Int Urogynecol J. 2019, in press. 86. Gansevoort RT, van Gastel MDA, Chapman AB, Blais JD, Czerwiec FS, Higashihara E, Lee J, Ouyang J, Perrone RD, Stade K, Torres VE, Devuyst O; TEMPO 3:4 Investigators. Plasma copeptin levels predict disease progression and tolvaptan efficacy in autosomal dominant polycystic kidney disease. Kidney Int. 96, 159-169, 2019. 87. Gonda K, Akama T, Nakamura T, Hashimoto E, Kyoya N, Rokkaku Y, Maejima Y, Horita S, Tachibana K, Abe N, Ohtake T, Shimomura K, Kono K, Saji S, Takenoshita S, Higashihara E. Cluster of differentiation 8 and programmed cell death ligand 1 expression in triple-negative breast cancer combined with autosomal dominant polycystic kidney disease and tuberous sclerosis complex: a case report. J Med Case Rep. 13, 381, 2019. 2018年 88. Fujimura T, Fukuhara H, Yamada Y, Taguchi S, Sugihara T, Niimi A, Nakamura M, Nakagawa T, Igawa Y, Homma Y, Kume H. Aggressive Cancer Behavior of Latent Gleason Pattern 5 in Prostatectomy Specimens. Anticancer Res. 38: 6529-6535, 2018. 89. Kinoshita Y, Sugihara T, Yasunaga H, Matsui H, Ishikawa A, Fujimura T, Fukuhara H, Ishibashi Y, Fushimi K, Homma Y. Hospital-volume effects on perioperative outcomes in peritoneal dialysis catheter implantation: analysis of 2,505 cases. Perit Dial Int. 38, 419-423, 2018. 90. Taguchi S, Fukuhara H*, Miyakawa J, Morikawa T, Naito A, Kawai T, Fujimura T, Kume H. Prognostic significance of neutrophil-to-lymphocyte ratio in collecting duct carcinoma. Jpn J Clin Oncol. 48, 692-694, 2018. 91. Otsuka M, Taguchi S, Nakagawa T, Morikawa T, Maekawa S, Miyakawa J, Matsumoto A, Miyazaki H, Fujimura T, Fukuhara H, Kume H, Igawa Y, Homma Y. Clinical significance of random bladder biopsy in primary T1 bladder cancer. Mol Clin Oncol. 8, 665-670, 2018. 92. Makino K, Nakagawa T, Ito E, Kasahara I, Murata T, Fujimura T, Fukuhara H, Homma Y. Oncological and peri-surgical outcomes of radical prostatectomy for non-metastatic prostate cancer with prostate-specific antigen level of 50 ng/ml or greater. Jpn J Clin Oncol. 48, 485-49, 2018. 93. Aizawa N, Watanabe D, Fukuhara H, Fujimura T, Kume H, Homma Y, Igawa Y. Inhibitory effects of silodosin on the bladder mechanosensitive afferent activities and their relaxation with bladder myogenic contractions in male rats with bladder outlet obstruction. Neurourol Urodyn. 37, 1897-1903, 2018. 94. Akiyama Y, Niimi A, Nomiya A, Yamada Y, Nakagawa T, Fujimura T, Fukuhara H, Kume H, Igawa Y and Homma Y. Extent of Hunner lesions: the relationships with symptom severity and clinical parameters in patients with Hunner-type interstitial cystitis. Neurourol Urodyn. 37, 1441-1447, 2018. 95. Niimi A, Igawa Y, Aizawa N, Honma T, Nomiya A, Akiyama Y, Kamei J, Fujimura T, Fukuhara H and Homma Y. Diagnostic value of urinary CXCL10 as a biomarker for predicting Hunner type interstitial cystitis. Neurourol Urodyn. 37, 1113-1119, 2018. 96. Yamada Y, Fujimura T, Fukuhara H, Sugihara T, Nakagawa T, Kume H, Igawa Y, Homma Y. Predictors of Early Continence after Robot-assisted Radical Prostatectomy. Low Urin Tract Symptoms. 10, 287-291, 2018. 97. Matsumoto A, Nakagawa T, Kanatani A, Ikeda M, Kawai T, Miyakawa J, Taguchi S, Naito A, Otsuka M, Nakanishi Y, Suzuki M, Koga F, Nagase Y, Kondo Y, Okaneya T, Tanaka Y, Miyazaki H, Fujimura T, Fukuhara H, Kume H, Igawa Y, Homma Y. Preoperative chronic kidney disease is predictive of oncological outcome of radical cystectomy for bladder cancer. World J Urol. 36, 249-256, 2018. 98. Arakawa K, Hata K, Yamamoto Y, Nishikawa T, Tanaka T, Kiyomatsu T, Kawai K, Nozawa H, Yoshida M, Fukuhara H, Fujishiro M, Morikawa T, Yamasoba T, Koike K, Fukayama M, Watanabe T. Nine primary malignant neoplasms-involving the esophagus, stomach, colon, rectum, prostate, and external ear canal-without microsatellite instability: a case report. BMC Cancer 18, 24, 2018. 99. Sato M, Taguchi A, Fukui Y, Kawata A, Taguchi S, Kashiyama T, Eguchi S, Inoue T, Tomio K, Tanikawa M, Sone K, Mori M, Nagasaka K, Adachi K, Ikemura M, Domoto Y, Arimoto T, Oda K, Fukayama M, Osuga Y, Fujii T. Blood Vessel Invasion Is a Strong Predictor of Postoperative Recurrence in Endometrial Cancer. Int J Gynecol Cancer 28, 875-881, 2018. 100. Higashihara E, Horie S, Kinoshita M, Harris PC, Okegawa T, Tanbo M, Hara H, Yamaguchi T, Shigemori K, Kawano H, Miyazaki I, Kaname S, Nutahara K. A potentially crucial role of the PKD1 C-terminal tail in renal prognosis. Clin Exp Nephrol. 22(2):395-404, 2018. 101. Okegawa T, Ninomiya N, Masuda K, Nakamura Y, Tambo M, Nutahara K. AR-V7 in circulating tumor cells cluster as a predictive biomarker of abiraterone acetate and enzalutamide treatment in castration-resistant prostate cancer patients．Prostate. 78(8):576-582, 2018 102. Fujita N, Tambo M, Terado Y, Fujita M, Okegawa T, Nutahara K. Vesicoenteric Fistula Arising from an Adenocarcinoma of Ectopic Pancreatic Tissue in a Meckel Diverticulum. Case Rep Oncol. 4;11(1):6-10, 2018. 103. Kinjo M, Yoshimura Y, Kitagawa Y, Okegawa T, Nutahara K. Sexual activity and quality of life in Japanese pelvic organ prolapse patients after transvaginal mesh surgery. J Obstet Gynaecol Res. 44(7):1302-1307, 2018 104. Yamaguchi T, Higashihara E, Okegawa T, Miyazaki I, Nutahara K.　Optimal equation for estimation of glomerular filtration rate in autosomal dominant polycystic kidney disease: influence of tolvaptan. Clin Exp Nephrol. 22(5):1213-1223, 2018. 105. Kinjo M, Sekiguchi Y, Yoshimura Y, Nutahara K. Long-term Persistence with Mirabegron versus Solifenacin in Women with Overactive Bladder: Prospective, Randomized Trial. Low Urin Tract Symptoms. 10, 148-151, 2018. 所属学会 日本ウイルス療法学会（副理事長）、日本遺伝子細胞治療学会（理事）、日本泌尿器内視鏡・ロボティクス学会（理事）、 日本泌尿器科学会（代議員）、日本癌学会（評議員）、日本癌治療学会（代議員）、日本尿路結石症学会（評議員）、泌尿器科分子・細胞研究会（評議員）、日本排尿機能学会（代議員）、 東京医学会、日本老年泌尿器科学会、日本内視鏡外科学会、日本ミニマム創泌尿器内視鏡外科学会、米国泌尿器科学会(AUA)、国際禁制学会(ICS)、日本泌尿器腫瘍学会、日本臨床腎移植学会、泌尿器腫瘍放射線(GUTR)研究会、日本間質性膀胱炎研究会 公的な委員会等の役員・委員歴 厚生労働省医師国家試験　医師試験委員 日本専門医機構　理事 東京地方裁判所　専門委員 学外活動多摩泌尿器科医会　会長 ひとことメッセージ がん治療用ウイルスを用いたウイルス療法の確立を目指しています。 患者さんに負担の少ない低浸襲性手術（ロボット支援手術、腹腔鏡下手術）を専門としています。 関連サイト 杏林大学病院泌尿器科学教室 医学研究科について 研究科概要 建学の精神と理念・目的 教育目標・３つのポリシー 文部科学省採択事業 研究科長あいさつ 学位取得 学修要綱 履修モデル・主要科目の特長 教育評価 専攻・専門分野 医学専攻 脳神経内科学分野医学専攻 呼吸器内科学分野医学専攻 腎臓・リウマチ膠原病内科学分野医学専攻 循環器内科学分野医学専攻 血液内科学分野医学専攻 消化器内科学分野医学専攻 糖尿病・内分泌・代謝内科学分野医学専攻 腫瘍内科学分野医学専攻 高齢医学分野医学専攻 精神神経科学分野医学専攻 小児科学分野医学専攻 消化器・一般外科学分野医学専攻 呼吸器・甲状腺外科学分野医学専攻 乳腺外科学分野医学専攻 小児外科学分野医学専攻 救急医学分野医学専攻 脳神経外科学分野医学専攻 心臓血管外科学分野医学専攻 整形外科学分野医学専攻 皮膚科学分野医学専攻 形成外科学分野医学専攻 泌尿器科学分野医学専攻 眼科学分野医学専攻 耳鼻咽喉科学分野医学専攻 産科婦人科学分野医学専攻 放射線医学分野医学専攻 放射線腫瘍学分野医学専攻 麻酔科学分野医学専攻 臨床検査医学分野医学専攻 総合医療学分野医学専攻 リハビリテーション医学分野医学専攻 脳卒中医学分野医学専攻 肉眼解剖学分野医学専攻 顕微解剖学分野医学専攻 統合生理学分野医学専攻 病態生理学分野医学専攻 代謝生化学分野医学専攻 細胞生化学分野医学専攻 薬理学分野医学専攻 病理学分野医学専攻 感染症学分野医学専攻 衛生学・公衆衛生学分野医学専攻 法医学分野医学専攻 ゲノム・遺伝学分野医学専攻 生体物理工学分野医学専攻 分子機能生化学分野 研究室・研究グループ 肉眼解剖学教室 顕微解剖学教室 生物学教室 代謝生化学教室 細胞生化学教室 化学教室 統合生理学教室 病態生理学教室 物理学教室 薬理学教室 病理学教室 感染症学教室 臨床検査医学教室 衛生学公衆衛生学教室 法医学教室 脳神経内科学教室 呼吸器内科学教室 腎臓・リウマチ膠原病内科学教室 循環器内科学教室 血液内科学教室 糖尿病・内分泌・代謝内科学教室 消化器内科学教室 腫瘍内科学教室 脳卒中医学教室 高齢医学教室 総合医療学教室 小児科学教室 精神神経科学教室 皮膚科学教室 放射線医学教室 放射線腫瘍学教室 消化器・一般外科学教室 呼吸器・甲状腺外科学教室 乳腺外科学教室 救急医学教室 整形外科学教室 リハビリテーション医学教室 脳神経外科教室 心臓血管外科学教室 産科婦人科学教室 眼科学教室 耳鼻咽喉科学教室 泌尿器科学教室 麻酔科学教室 小児外科学教室 形成外科学教室 教員紹介 指導教員・研究分野 担当教員一覧 共同研究施設 電子顕微鏡部門 放射性同位元素部門 フローサイトメトリー部門 蛋白質・核酸解析部門 生体機能実験部門 実験動物施設部門 受験生の皆様へ 募集要項 入試日程 外国語試問 社会人大学院生 学納金・奨学金 在学生・卒業生の方へ 各種届出様式 証明書の交付・各種願・届出 学位申請 行事予定 授業科目・シラバス 医学研究講義 I 医学研究講義 II 関連サイト 医学部 付属病院 杏林大学図書館 研究推進センター 杏林医学会 がんプロ 関連リンク このサイトでは、メニューの表示に Javascript を使用しています。Javascript をオンにしていただくか、「サイトマップ」から各ページをご覧ください。 医学研究科へのお問い合わせ プライバシーポリシー｜このサイトについて｜関連リンク｜ストレスチェック｜職員e-ラーニングｽﾏｰﾄﾌｫﾝｻｲﾄ--> COPYRIGHT KYORIN UNIVERSITY. 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